Kirk Lohmueller


Research Overview

My research is focused on human population genetics. I combine the analysis of large-scale genomic datasets with predictions made from population genetic models to learn about human evolution. Specific interests include learning about ancient human history from genomic data, understanding how natural selection operates across the genome, and determining how population history and natural selection interact.

I am also interested in various statistical genetic aspects of forensic DNA analysis. My efforts here are currently focused on evaluating and improving statistical methods for interpreting low-template DNA profiles.

Selected Publications

Lohmueller KE, Bustamante CD, Clark AG. Detecting directional selection in the presence of recent admixture in African Americans. Genetics, in press.

Boyko A, Quignon P, Li L, Schoenebeck J, Degenhardt JD, Lohmueller KE, et al. A simple genetic architecture underlies quantitative traits in dogs, PLoS Biology 2010; 10: 31000451.

Lohmueller KE, Bustamante CD, Clark AG. The effect of recent admixture on inference of ancient population history. Genetics 2010; 185:611-622.

Lohmueller KE, Degenhardt JD, Keinan A. (Letter to the Editor) Sex-averaged recombination and mutation rates: A comment on Labuda et al., Am J Hum Genet 2010; 86:978-980.

Lohmueller KE. (Letter to the Editor) Graydon et al. provide no new evidence that forensic STR loci are functional. Forensic Sci Int Genet 2010; 4:273-274.

vonHoldt BM, Pollinger JP, Lohmueller KE, et al. Genome-wide SNP and haplotype analysis reveals a rich history underlying dog domestication. Nature 2010; 464:898-902.

Wall JD, Lohmueller KE, Plagnol V. Detecting ancient admixture and estimating demographic parameters in multiple human populations. Mol Biol Evol 2009; 26:1823-1827.

Lohmueller KE, Bustamante CD, Clark AG. Methods for human demographic inference using haplotype patterns from genome-wide SNP data. Genetics 2009; 182:217-231.

Auton A, Bryc K, Boyko AR, Lohmueller KE, et al.. Global distribution of genomic diversity underscores rich complex history of continental human populations. Genome Research 2009; 19:795-803.

Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, et al.. Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genetics 2008; 4: e1000083.

Lohmueller KE, et al. Proportionally more deleterious genetic variation in European than in African populations. Nature 2008; 451:994-997.

Lohmueller KE, Pierce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003; 33:177-182.