Matteo Fumagalli


Research Overview

My research focuses on developing and applying new statistical methods to detect natural selection signatures in the human genome. In particular, I am interested in identifying signals of genetic adaptation to different environmental conditions, especially whether they are due to non-classical selective events, like selection from standing variation or polygenic adaptation. I am also interested in developing methods to perform association studies or population genetics analyzes using next-generation sequencing data.

Selected Publications

Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. Fumagalli M, Sironi M, Pozzoli U, Ferrer-Admettla A, Pattini L, Nielsen R. PLoS Genet. 2011, in press.

Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes. Fumagalli M, Cagliani R, Riva S, Pozzoli U, Biasin M, Piacentini L, Comi GP, Bresolin N, Clerici M, Sironi M. Mol Biol Evol. 2010 Nov;27(11):2555-66. Epub 2010 Jun 10.

Genome-wide identification of susceptibility alleles for viral infections through a population genetics approach. Fumagalli M, Pozzoli U, Cagliani R, Comi GP, Bresolin N, Clerici M, Sironi M. PLoS Genet. 2010 Feb 19;6(2):e1000849.

Diverse evolutionary histories for beta-adrenoreceptor genes in humans. Cagliani R, Fumagalli M, Pozzoli U, Riva S, Comi GP, Torri F, Macciardi F, Bresolin N, Sironi M. Am J Hum Genet. 2009 Jul;85(1):64-75. Epub 2009 Jul 2.

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. Fumagalli M, Pozzoli U, Cagliani R, Comi GP, Riva S, Clerici M, Bresolin N, Sironi M. J Exp Med. 2009 Jun 8;206(6):1395-408. Epub 2009 May 25.

Widespread balancing selection and pathogen-driven selection at blood group antigen genes. Fumagalli M, Cagliani R, Pozzoli U, Riva S, Comi GP, Menozzi G, Bresolin N, Sironi M. Genome Res. 2009 Feb;19(2):199-212. Epub 2008 Nov 7.